Elsevier

Neurocomputing

Volumes 52–54, June 2003, Pages 169-175
Neurocomputing

Electric field modulation of synchronization in neuronal networks

https://doi.org/10.1016/S0925-2312(02)00820-2Get rights and content

Abstract

Motivated by the observation that applied electric fields modulate hippocampal seizures, and that seizures may be asynchronous, we modeled synaptically coupled two-compartment hippocampal pyramidal neurons embedded within an electrically resistive lattice in order to examine network synchronization properties under the influence of externally applied electric fields. Excitatory electric fields were shown to synchronize or desynchronize the network depending on the natural frequency mismatch between the neurons. Such frequency mismatch was found to decrease as a function of increasing electric field amplitude. These findings provide testable hypotheses for future seizure control experiments.

Section snippets

Eun-Hyoung Park received Ph.D. degree in nonlinear dynamics, physics in 2000 Dec. at Potsdam University in Germany. Since March 2001, she is now a postdoc at the Krasnow Institute at George Mason University, Virginia, working on computational modeling, specifically pyramidal cell in hippocampus.

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Cited by (0)

Eun-Hyoung Park received Ph.D. degree in nonlinear dynamics, physics in 2000 Dec. at Potsdam University in Germany. Since March 2001, she is now a postdoc at the Krasnow Institute at George Mason University, Virginia, working on computational modeling, specifically pyramidal cell in hippocampus.

Paul So

Ernest Barreto

Bruce J. Gluckman

Steven J. Schiff

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