Original contributionIn vivo and ex vivo study of metabolic and cellular effects of 5-fluorouracil chemotherapy in a mouse mammary carcinoma
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Cited by (8)
Metabolomic studies of breast cancer in murine models: A review
2020, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :Also, most studies on these models have addressed the metabolic response to different therapeutics, along with the study of particular diets or simply the search for tumor metabolic biomarkers, compared to controls; in this section, all studies will be discussed for the corresponding common carcinogenic compound. The first studies on carcinogen-induced models were, to our knowledge, carried out on 3-methylcholantrene-induced models, using 31P-NMR to characterize tumor extracts, in tandem with in vivo 31P-MRS [67–69], during time-course treatment with the alkylating drug CPA [67] and the anti-metabolite 5-flurouracil (5-FU) [68] (Table 4). In the former case, CPA was chosen because the drug is believed to have a similar mechanism of action as radiation and the authors aimed to pinpoint the metabolic changes expected with radiation therapy.
In vivo magnetic resonance spectroscopy in cancer
2005, Annual Review of Biomedical Engineering