Elsevier

Experimental Gerontology

Volume 32, Issues 1–2, January–April 1997, Pages 79-86
Experimental Gerontology

Mouse and rat genotype choices

https://doi.org/10.1016/S0531-5565(96)00035-6Get rights and content

Abstract

There are advantages and disadvantages to all animal models for aging research. Investigators need to understand these issues, as well as the nature of each relevant model, to choose the best model for their research. There is no “best” or “worst” model for aging research. Five genetically defined rodent models of potential utility in aging research are: (1) inbred strains and F1 hybrid mice and rats, (2) single gene mutations and other single locus effects, (3) congenic lines, (4) recombinant Inbred (RI) strains, and (5) genetically selected strains and stocks. Animals of each of these types are available for research, but only inbred and F1 hybrid mice and rats are commercially available as aged animals. A general understanding of the need for careful genetic definition and for the best available barrier-breeding facilities has improved the quality of aging research significantly in the last two decades.

References (15)

  • T. Takeda et al.

    A new murine model of accelerated senescence

    Mech. Ageing Dev.

    (1981)
  • D.W. Bailey

    Recombinant inbred strains; An aid in finding identity linkage, and function of histocompatibility and other genes

    Transplantation

    (1971)
  • R.T. Bronson

    Rate of occurrence of lesions in 20 inbred and hybrid genotypes of rats and mice sacrificed at 6 month intervals during the first years of life

  • M.E. Elias et al.

    Hormones, aging and behavior in infra human mammals

  • E. Green

    Breeding systems

  • D.G. Hazzard et al.

    Selection of an appropriate animal model to study aging processes with special emphasis on the use of rat strains

    J. Gerontol.

    (1992)
  • T.E. Johnson

    Increased life-span of age-1 mutants in Caenorhabditus elegans, and lower Gomperts rate of aging

    Science

    (1990)
There are more references available in the full text version of this article.

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