Nerve growth factor receptor in tumours of the human nervous system: Immunohistochemical analysis of receptor expression and tumour growth fraction

doi:10.1016/S0344-0338(89)80008-1

Pathology - Research and Practice

Volume 185, Issue 3, September 1989, Pages 332-338

https://doi.org/10.1016/S0344-0338(89)80008-1 Get rights and content

Summary

The expression of nerve growth factor receptor (NGFr) was investigated by means of immunohistochemistry in 135 tumours of the human central and peripheral nervous system. The results were compared to the proliferative activity of the tumours as determined by immunostaining for the proliferation-associated antigen Ki-67. Immunoreactivity for NGFr was most consistently observed in tumours derived from the neural crest such as neurinomas, neurofibromas and ganglioneuromas. In tumours of the central nervous system, NGFr-immunostaining was particularly strong in pilocytic astrocytomas while the majority ofother gliomas were either NGFr-negative or contained only a minor fraction of NGFr-positive tumour cells. Among all other investigated tumours including medulloblastomas, pituitary adenomas and meningiomas only exceptional cases demonstrated a significant number of positive tumour cells. Choroid plexus papillomas and metastatic carcinomas were always NGFr-negative. Our results indicate that NGFr-expression in tumours of the human nervous system is heterogeneous with respect to tumour type and appears to be unrelated to proliferative activity.

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: Supported by Deutsche Forschungsgemeinschaft, SFB 200.

¹: Prof. Dr. W. Wechsler, Department of Neuropathology, University of Düsseldorf, Moorenstraße 5, D-4000 Düsseldorf 1, FRG

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Nerve growth factor receptor in tumours of the human nervous system: Immunohistochemical analysis of receptor expression and tumour growth fraction

Summary

J Biol Chem

Biochem Biophys Acta

Neurone

J Biol Chem

Exp Cell Res

Gene transfer and molecular cloning of the human NGF receptor

Science

Immunohistochemical analysis of nerve growth factor receptor expression in normal and malignant human tissues

J Histochem Cytochem

Determination of the proliferative potential of human brain tumors using the monoclonal antibody Ki-67

J Cancer Res Clin Oncol

Nerve growth factor receptors on human melanoma cells in culture

Proc Natl Acad Sci USA

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67

J Immunol

Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation

Int J Cancer

Growth factors and cancer

Cancer Res

Affinity labeling and partial purification of nerve growth factor receptors from rat pheochromocytoma and human melanoma cells

Proc Natl Acad Sci USA

Properties of the beta nerve growth factor receptor of avian dorsal root ganglia

Proc Natl Acad Sci USA

The use of anti-avidin antibody and avidin-biotin-peroxidase-complex in immunoperoxidase techniques

Am J Clin Pathol

The nerve growth factor receptor gene is at human chromosome region l7q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias

Proc Natl Acad Sci USA