Elsevier

Neuroscience Letters

Volume 330, Issue 1, 13 September 2002, Pages 65-68
Neuroscience Letters

Age-related upregulation of insulin-like growth factor receptor type I in rat cerebellum

https://doi.org/10.1016/S0304-3940(02)00740-1Get rights and content

Abstract

We investigated age-related changes in insulin-like growth factor-I (IGF-I) receptor localization in the cerebellum using immunohistochemical staining. In adult rats, no immunoreactivity for IGF-I receptor was found in any layers of cerebellar cortex. In contrast, IGF-I receptor immunoreactivity was found in the cerebellar cortex of aged rats. The most prominent labeling was localized in the Purkinje cell layers and molecular layers. The cerebellar output neurons showed little immunoreactivity for IGF-I receptor in the nucleus medialis, interpositus and lateralis of adult rats. In aged cerebellar nuclei, IGF-I receptor immunoreactivity was observed in the surrounding neuropil. The first demonstration of upregulation of IGF-I receptor in aged rat cerebellum suggests that IGF-I may promote the survival of a degenerated population of the Purkinje neurons by increases in IGF-I receptor expression during aging.

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Acknowledgements

This study was supported by a grant of the Biomedical Brain Research Center, Ministry of Health & Welfare, Republic of Korea (01-PJ8-PG6-01NE01-0003). This study was supported in part by year 2002 BK21 project for Medicine, Dentistry and Pharmacy.

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Chung Min Shin and Yoon Hee Chung are equal contributors to this work.

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