Age-related upregulation of insulin-like growth factor receptor type I in rat cerebellum
Section snippets
Acknowledgements
This study was supported by a grant of the Biomedical Brain Research Center, Ministry of Health & Welfare, Republic of Korea (01-PJ8-PG6-01NE01-0003). This study was supported in part by year 2002 BK21 project for Medicine, Dentistry and Pharmacy.
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The effects of lead exposure on the expression of IGF1R, IGFBP3, Aβ40, and Aβ42 in PC12 cells
2022, Journal of Trace Elements in Medicine and BiologyCitation Excerpt :The increase in IGF1 signal transduction activation downstream of IGF1R is expected to occur in the brain of the elderly with important functional consequences. For example, the hippocampus is an important brain area of learning and memory, the increase of IGF1R level is related to learning deficit in rats [11], and maternal low level of lead exposure can also reduce the cognitive ability of young rats [12]. The study has clearly confirmed that the low expression of IGF1R in the hippocampus may lead to learning and memory disorders associated with maternal lead exposure [13], with decreased expression of IGF1R accompanied by neurodegenerative changes.
Aging of the brain, neurotrophin signaling, and Alzheimer's disease: Is IGF1-R the common culprit?
2008, Neurobiology of AgingCitation Excerpt :Therefore, loss of p53 activity leads to accelerated cell growth (and cancers), whereas increased p53 activity leads to early arrest of cell growth, premature aging, and increased production of Aβ (see later). Although IGF1 levels in the cerebrospinal fluid (CSF) exhibit no change or a slight increase during aging (Carro and Torres-Aleman, 2004), the expression levels of the receptor (IGF1-R) show a dramatic and progressive increase in both cortex and hippocampus that correlates with learning deficits in aged rats (Chung et al., 2002a,b; Stenvers et al., 1996). A recent study in the brain of normally aged individuals has also found an age-associated increase in the expression of IR (Lu et al., 2004).
Cochlear ablation in adult ferrets results in changes in insulin-like growth factor-1 and synaptophysin immunostaining in the cochlear nucleus
2007, NeuroscienceCitation Excerpt :Evidence suggests that neurotrophic factors are activity-dependent molecular signals that play an important role in restoring neuronal function and synaptic plasticity after deafferentation (Suneja et al., 2005). Since afferent activity can modulate the synthesis, secretion and action of growth factors (Gomez-Pinilla et al., 2004), activity-dependent increases in the levels of these molecules have been suggested to constitute a neuroprotective mechanism against brain injury (Chung et al., 2002). Accordingly, increases in growth factor levels have been found in the lateral superior olive and the cochlear nucleus after unilateral cochlear ablation in adult guinea pigs (Suneja et al., 2005).
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Chung Min Shin and Yoon Hee Chung are equal contributors to this work.