Elsevier

Nutrition Research

Volume 13, Issue 3, March 1993, Pages 297-307
Nutrition Research

Tissue specific regulation of lipogenesis by carbohydrate feeding and twenty four hour starvation in the rat

https://doi.org/10.1016/S0271-5317(05)80426-9Get rights and content

Abstract

The effects of high carbohydrate (HC), low fat feeding and 24 hour starvation on lipogenesis in different rat tissues were investigated, using the incorporation of tritiated water. HC feeding stimulated lipogenesis in liver (5.5 fold) and also to a lesser extent in inner white fat depots, interscapular brown fat, kidney and heart. Tritium incorporation into lipids in large intestine was inhibited under the same circumstances. All other tissues, including lung, skin and brain were unaffected. Twenty four hour starvation diminished lipogenesis, particularly in liver, but also in brown adipose tissue, kidney, heart, lung and small and large intestines. The contribution of different tissues to total lipogenesis depended on the nutritional state. Skin and bone and muscle predominated in the starved animals, whereas liver alone contributed 56% in the HC group. TLC analysis of the labeled lipids confirmed in most cases that the tritium was incorporated into fatty acids. However HC feeding diminished cholesterol labeling in liver and in large intestine. Thus the reduction in lipogenesis in large intestines from rats on the HC diet was due to a drop in cholesterol synthesis, with fatty acids being unaffected. There is great variation in the sensitivity of lipogenesis in different tissues to nutritional manipulation, providing an interesting model for the study of tissue specific regulatory processes.

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