Trends in Biotechnology
focusStructure-function relationships of hammerhead ribozymes: from understanding to applications
References (29)
- et al.
Biochim. Biophys. Acta
(1994) - et al.
Bio-org. Med. Chem. Lett.
(1994) - et al.
Biochim. Biophys. Acta
(1993) - et al.
J. Biol. Chem.
(1994) Annu. Rev. Biochem.
(1992)- et al.
Nucleic Acids Res.
(1990) - et al.
Biochemistry
(1991) - et al.
Nucleic Acids Res.
(1991) - et al.
Biochemistry
(1991) - et al.
Biochemistry
(1993)
J. Am. Chem. Soc.
J. Am. Chem. Soc.
Nucleic Acids Res.
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Computational methods for prediction of RNA interactions with metal ions and small organic ligands
2015, Methods in EnzymologyCitation Excerpt :The RNA backbone is negatively charged and the neutralization of the electrostatic repulsion by the binding of cations is essential for the formation of compact tertiary structures that are functionally important [reviews: Draper, 2004, 2008; Serra et al., 2002]. Moreover, metal ions also often serve as essential cofactors in the active sites of ribozymes; i.e., RNAs that function as enzymes like the hammerhead ribozyme, self-splicing introns, and ribonuclease P (RNaseP) (Schnabl & Sigel, 2010; Sigurdsson & Eckstein, 1995). Binding of ligands is also an important function of some riboswitches; e.g., mRNA-embedded noncoding elements that regulate the translation of the coding part of RNA by undergoing conformational changes (Montange & Batey, 2008).
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