Hyperactivity, hyper-reactivity, and sensorimotor deficits induced by low doses of the N-methyl-d-aspartate non-competitive channel blocker MK801
References (39)
- et al.
Effects of NMDA receptor/channel antagonists CPP and MK801 on hippocampal field potentials and long-term potentiation in anesthetized rats
Brain Res.
(1988) - et al.
Flavor-illness aversions: the role of the amygdala in the acquisition of taste-potentiated odor aversions
Physiol. Behav.
(1986) A novel antagonist MK801 impairs performance in a hippocampal-dependent spatial learning task
Pharmacol. Biochem. Behav.
(1989)- et al.
MK-801 blocks NMDA receptor-mediated synaptic transmission and long-term potentiation in rat hippocampal slices
Neurosci. Lett.
(1987) - et al.
Anatomical organization of excitatory amino acid receptors and their pathways
Trends. Neurosci.
(1987) - et al.
Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by D(−) aminophosphonovalerate
Neuroscience
(1987) - et al.
The topography of MK-801-induced locomotor patterns in rats
Physiol. Behav.
(1989) - et al.
MK801 and AP5 impair acquisition but not retention of the Morris milk maze
Pharmacol. Biochem. Behav.
(1990) Dorsal and ventral hippocampal lesions and behavior
Physiol. Behav.
(1968)- et al.
Spatial memory and hippocampal function
Neuropsychologia
(1979)
The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor
Eur. J. Pharm.
Near-total loss of ‘learing’ and ‘memory’ as a result of combined cholinergic and serotonergic blockade in the rat
Behav. Brain Res.
‘Stick out your tongue’: tongue protrusion in neocortex and hypothalamic damaged rats
Physiol. Behav.
The interaction between MK-801 and receptors for N-methyl-d-asparate: functional consequences
Neuropharmacology
MK-801 and combined propranol with MK-801 produce motor deficits but do not impair learning in the water task
Effects of the NMDA receptor antagonist MK-801 on LTP in freely behaving rats
Neurosci. Abstr.
Excitatory amino acids in synaptic transmission in the schaffer collateral-commissural pathway of the rat hippocampus
J. Physiol.
Exploration-dependent enhancement of synaptic responses in rat fascia dentata is blocked by MK801
Neurosci. Abstr.
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Sex-specific behavioral impairments produced by neonatal exposure to MK-801 are partially reversed by adolescent CDPPB treatment
2022, Neurotoxicology and TeratologyPsychotomimetic effects of different doses of MK-801 and the underlying mechanisms in a selective memory impairment model
2017, Behavioural Brain ResearchCitation Excerpt :However, a variety of psychotomimetic effects, including hyperlocomotion, sensorimotor deficits and affection changes were also observed [15,27]. These non-cognitive side effects have long been recognized to confound the performance of animals in memory tests, and may mask real cognitive effects in studies [25,26,31]. Therefore, it is crucial to disassociate the memory impairments from those side effects.
Effects of the GluN2B-NMDA receptor antagonist Ro 25-6981 on two types of behavioral flexibility in rats
2017, Behavioural Brain ResearchCitation Excerpt :These are important observations, since they suggest a highly selective role of GluN2B subunits in spatial, navigational behavior. Further, these data indicate that drug treatment did not induce non-specific sensory-motor deficits or other behavioral side-effects that are often observed with NMDAR antagonists and that can lead to performance impairments in tasks assessing learning and memory functions in rodents [14,15]. The results reported here confirm previous work demonstrating reversal learning deficits in spatial and operant tasks following GluN2B disruptions.
Pre-training in a radial arm maze abolished anxiety and impaired habituation in C57BL6/J mice treated with dizocilpine
2016, Physiology and BehaviorCitation Excerpt :Hence, it appears that NMDA receptor-dependent synaptic plasticity is not necessary in all forms of learning. MK-801 at 1 and 0.05 mg/kg have been reported to induce alterations in both sensory processing and motor performance that interfere with learning [3,37,44,108]. In the present study, these sensory-motor disturbances were not apparent though our data revealed that pre-trained mice were hyperactive.
Enhanced attention and impulsive action following NMDA receptor GluN2B-selective antagonist pretreatment
2016, Behavioural Brain Research