The economics of neurite outgrowth — the addition of new membrane to growing axons

doi:10.1016/S0166-2236(96)80025-7

Trends in Neurosciences

Volume 19, Issue 4, April 1996, Pages 144-149

https://doi.org/10.1016/S0166-2236(96)80025-7 Get rights and content

Abstract

Recent studies have shown that axonal growth is disrupted by treatments that block the synthesis of membrane components or their delivery by microtubule-based transport. This implies that a continuous supply of newly synthesized membrane components is necessary to sustain growth. In contrast, no clear consensus has yet been achieved about the site of insertion of new membrane components in the membrane of the growing axon, despite the application of new and refined biophysical and molecular techniques to the study of this issue. Until the site of insertion of new membrane components is resolved, little progress can be made in defining the feedback mechanisms by which the supply of new membrane components is co-ordinated with the demands of growth, particularly in cases where the dynamics of neurite growth change from minute to minute.

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¹: Anthony H. Futerman is at the Dept of Membrane Research and Biophysics, Wiezmann Institute of Science, Rehovot 76100, Israel and Gary A. Banker is at the Dept of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

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Trends in Neurosciences

ReviewThe economics of neurite outgrowth — the addition of new membrane to growing axons

Abstract

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Nature

Review
The economics of neurite outgrowth — the addition of new membrane to growing axons