Research paperIn vivo saturation kinetics of two dopamine transporter probes measured using a small animal positron emission tomography scanner
References (33)
- et al.
Regional brain uptake and pharmacokinetics of [123I]N-ω-fluoroalkyl-2β-carboxy-3β-(4-iodophenyl)nortropane esters in baboons
Nucl Med Biol
(1995) - et al.
The potential of high-resolution positron emission tomography to monitor striatal dopaminergic function in rat models of disease
J Neurosci Methods
(1996) - et al.
Evaluation of [11C]RTI-121 as a selective radioligand for PET studies of the dopamine transporter
Nucl Med Biol
(1996) - et al.
Quantification of dopamine receptors and transporter in rat striatum using a small animal PET scanner
- et al.
In vivo evaluation of 11C- and 18F-labelled cocaine analogues as potential dopamine transporter ligands for positron emission tomography
Nucl Med Biol
(1996) - et al.
[3H]WIN 35,428 binding in the caudate nucleus of the rabbit: evidence for a single site on the dopamine transporter
J Pharmacol Exp Ther
(1995) - et al.
The design and physical characteristics of a small animal positron emission tomograph
Phys Med Biol
(1995) - et al.
Selective labeling of the dopamine transporter by the high affinity ligand 3β-(4-[125I]iodophenyl)tropane-2β-carboxylic acid isopropyl ester
Mol Pharmacol
(1995) - et al.
Selective dopamine transporter inhibition by cocaine analogs
NeuroReport
(1992) - et al.
[11C]RTI-121—A potential radioligand for PET studies of the dopamine transporter
J Labelled Compd Radiopharm
(1994)
Synthesis of the dopamine re-uptake marker [124I]RTI-121
J Labelled Compd Radiopharm
Synthesis of a radiotracer for studying dopamine uptake sites in vivo using PET: 2β-carbomethoxy-3β-(4-fluorophenyl)-[N-11C-methyl]tropane ([11C]CFT or [11C]WIN-35,428
J Labelled Compd Radiopharm
Conditioned taste aversion and operant behavior in rats: effects of cocaine, apomorphine and some long-acting derivatives
J Pharmacol Exp Ther
Examination of [C-11]β-CIT-FP and [C-11]β-CIT-FE uptake in the human brain by PET
J Nucl Med
PET study of [11C]β-CIT binding to monoamine transporters in the monkey and human brain
Synapse
Positron emission tomographic imaging of the dopamine transporter with 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease
Ann Neurol
Cited by (31)
Real-time assessment of bone metabolism in small animal models forosteoarthritis using multi pinhole-SPECT/CT
2013, Osteoarthritis and CartilageCitation Excerpt :A few small animal imaging techniques are already implemented for the longitudinal assessment of osteoarthritis3 of which micro-computed tomography (μCT)4,5 and magnetic resonance imaging (MRI)6 are the most well-known. Recently, high resolution molecular imaging techniques became available for small animal imaging, including multi-pinhole single photon emission computed tomography (MPH-SPECT)7 and micro-positron emission tomography (micro-PET)8. These functional imaging modalities provide the opportunity to assess biological processes in real-time in contrast to structural imaging modalities (e.g., CT or MRI) which provide the results of these processes over a longer period of time.
Applications for preclinical PET/MRI
2013, Seminars in Nuclear MedicineCitation Excerpt :Having sufficient sensitivity is a particularly important requirement because it is necessary to collect a sufficient number of counts in a reasonable amount of time and for a reasonable injected dose while ensuring that only trace amounts of the radiolabeled compound are injected to avoid saturation of the biological target under study. This is even more important if isotopes with short half-lives, like 11C, and/or compounds yielding only limited specific activity are to be used, which often is the case in many applications of radioligands for brain receptor imaging.26,27 It becomes apparent from Figure 1 and Table 1 that all available prototype PET/MRI scanners for which published data exist are still some way from providing the desired combination of sensitivity and high spatial resolution for in vivo small animal imaging (refer to highlighted area in the chart).
Dopamine transporter binding in rat striatum: a comparison of [O-methyl-<sup>11</sup>C]β-CFT and [N-methyl-<sup>11</sup>C]β-CFT
2009, Nuclear Medicine and BiologyAmyloid Imaging: From Benchtop to Bedside
2005, Current Topics in Developmental BiologyCitation Excerpt :They have also become an indispensable tool in the drug discovery process to bridge the gap between laboratory research and clinical applications. Recent examples include evaluation of tumor metabolism and proliferation (Brock et al., 2000; Shields et al., 1998a), drug receptor interaction (Anderson et al., 2001; Hume et al., 1997; Kapur et al., 1997a,b,c), modulation of multidrug resistance (Chen et al., 1997; Hendrikse et al., 1999a,b; Levchenko et al., 2000; Vecchio et al., 1997), quantitating angiogenensis and antivascular activity (Vavere and Lewis, 2003; Weber et al., 2001), detection of apoptosis (Blankenberg and Strauss, 2001; Blankenberg et al., 2001; Narula et al., 2001), tumor hypoxia (Casciari et al., 1995; Foo et al., 2004; Lewis et al., 2002), therapy response, and gene expression (Blasberg, 2002; Blasberg and Gelovani‐Tjuvajev, 2002; Dehdashti et al., 1999; Gambhir et al., 1999; Herschman, 2004; Shields et al., 1998b; Walker and Zigler, 2003; Walker et al., 2004). In AD, anti‐amyloid therapies are currently under development to halt or reverse the progressive accumulation of Aβ deposit in AD brain.
Small Animal PET Systems
2004, Emission Tomography: The Fundamentals of PET and SPECT
- 1
Present address: PET Centre, Free University Hospital, PO Box 7057, 1007 MB Amsterdam, Netherlands.