Effect of the infusion of the GABA-A receptor agonist, muscimol, on the role of the entorhinal cortex, amygdala, and hippocampus in memory processes
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Cited by (40)
Alteration of transcriptional networks in the entorhinal cortex after maternal immune activation and adolescent cannabinoid exposure
2016, Brain, Behavior, and ImmunityCitation Excerpt :In the mammalian brain, all three GABA receptor subunit isoforms are associated with schizophrenia (Ishikawa et al., 2004; Zai et al., 2009) and in this study we found expression of all three isoforms to be significantly downregulated in the combined treatment group. This has significant potential to disturb the GABAA receptor complex in the EC, leading to profound disturbances in learning and memory consolidation (Izquierdo and Medina, 1991; Izquierdo et al., 1990; Jerusalinsky et al., 1994; Berry et al., 2008; Zilles et al., 2000). Our data suggests that a dual environmental insult may alter numerous schizophrenia-associated neurotransmission systems through miRNA-mRNA interactions, transcription factors, signal transduction molecules and associated pathways.
Modulation of muscimol state-dependent memory by α<inf>2</inf>- adrenoceptors of the dorsal hippocampal area
2013, European Journal of PharmacologyCitation Excerpt :Our results show that pre-training and/or pre-test intra-dorsal hippocampal (intra-CA1) administration of certain dose of the GABAA receptor agonist, muscimol impaired memory retrieval in the step-down passive avoidance task. These results are in agreement with our previous studies (Jafari-Sabet and Jannat-Dastjerdi, 2009; Jafari-Sabet, 2011) and other investigators who found that muscimol impaired memory formation (Jerusalinsky et al., 1994; Castellano et al., 1996; Farr et al., 2000; Chapouthier, 2004; Amaral et al., 2007), indicating the possible existence of an inhibitory influence of the brain GABAA system on memory. Furthermore, our results also indicate that pre-training administration of muscimol induced memory impairment which is restored when the same dose of the drug is administered 24 h later in a pre-test session.
Prolonged inactivation of the hippocampus reveals temporally graded retrograde amnesia for unreinforced spatial learning in rats
2011, Neurobiology of Learning and MemoryCitation Excerpt :These injections presumably maintained the hippocampus in a deactivated mode for 4–5 days, as the effects of the muscimol injections at the end of the fourth day likely persisted for at least 12 h (Majchrzak & Di Scala, 2000). The same volume of muscimol, as used in the present study, resulted in poor performance on several learning and memory tasks when injected in the dorsal hippocampus of rats (Gaskin & White, 2009; Holt & Maren, 1999; Jerusalinsky et al., 1994; Mao & Robinson, 1998; Maren & Holt, 2004; White & Gaskin, 2006). Testing for the S3h group and M3h group occurred 4 days after the last saline or muscimol injection.
Involvement of dorsal hippocampal muscarinic cholinergic receptors on muscimol state-dependent memory of passive avoidance in mice
2011, Life SciencesCitation Excerpt :The present data show that pre-training intra-dorsal hippocampal (intra-CA1) administration of different doses of the GABA-A receptor agonist, muscimol impaired memory retrieval in the step-down passive avoidance task. These results are in agreement with our previous study (Jafari-Sabet and Jannat-Dastjerdi, 2009) and other investigators who found that muscimol impaired memory formation (Jerusalinsky et al., 1994; Castellano et al., 1996; Farr et al., 2000; Chapouthier, 2004; Amaral et al., 2007), indicating the possible existence of an inhibitory influence of the brain GABA-A system on memory. Furthermore, our results also indicate that impairment of memory formation induced by acute pre-training muscimol injection can be reversed by pre-test muscimol in a time- and dose-specific manner.
Muscimol state-dependent memory: Involvement of dorsal hippocampal μ-opioid receptors
2009, Behavioural Brain Research
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We are grateful to Dr. Graham L. Collingridge of the University of Birmingham for his gift of CNQX.