Chronic administration of Org2766 and morphine counteracts isolation-induced increase in social interest: implication of endogenous opioid systems
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Cited by (18)
HIV-1 Tat and morphine decrease murine inter-male social interactions and associated oxytocin levels in the prefrontal cortex, amygdala, and hypothalamic paraventricular nucleus
2021, Hormones and BehaviorCitation Excerpt :We found that repeated administration of morphine decreased non-aggressive and aggressive interactions in the resident-intruder test. One possible explanation is that administering μ-opioid receptor (MOR) agonists decreases sociability, whereas opioid receptor antagonists increase sociability in isolated adult rodents, but not in grouped-housed mice (Hol et al., 1996; Puglisi-Allegra et al., 1982; Slamberova et al., 2016). These data suggest that MOR agonists may replace the need for social interaction, although in a few studies β-endorphin increased sociability in previously isolated rats (Niesink and van Ree, 1984; van Ree and Niesink, 1983).
Impact of housing conditions on social behavior, neuroimmune markers, and oxytocin receptor expression in aged male and female Fischer 344 rats
2019, Experimental GerontologyCitation Excerpt :It has been established that effects of social deprivation (i.e., isolation housing) on subsequent social interaction differ as a function of age. Long-term social isolation of juveniles and adolescents generally decreases adult social behavior (Hol et al., 1999; Van Den Berg et al., 1999), and similar social isolation of adults increases interaction with conspecifics (Hol et al., 1996; Latane et al., 1972). Effects of social isolation in aged rats have been poorly investigated.
Opioid addiction: Who are your real friends?
2017, Neuroscience and Biobehavioral ReviewsCitation Excerpt :These effects largely depend upon the developmental stage when isolation occurred. Isolation during adulthood or a short-term social isolation of juveniles actually increases social behaviors, e.g. social play and social grooming (Niesink and Van Ree, 1989; Vanderschuren et al., 1995; Hol et al., 1996). As noted above, social isolation of females also influences social behaviors, but to a diminished magnitude and typically influencing phenotypically different (i.e. less aggressive) behaviors.
Aging-related changes in the effects of social isolation on social behavior in rats
2011, Physiology and BehaviorCitation Excerpt :For example, isolation from mothers during early life, i.e. maternal deprivation, impairs adult intermale aggression, social learning, and maternal aggression in rats [17–20]. Moreover, long-term isolation (two and more weeks) after weaning decreased adult social behavior, such as social exploration, sniffing, and approach/following [21–23] while long-term isolation in adulthood increased subsequent social behavior [24–26]. Thus, it has been indicated that long-term isolation differentially affects subsequent social behavior depending on the age at isolation.
Effects of fluoxetine and PCPA on isolation-induced morphine self-administration and startle reactivity
2010, Pharmacology Biochemistry and BehaviorPrior morphine experience induces long-term increases in social interest and in appetitive behavior for natural reward
2007, Behavioural Brain Research