Biodegradation and distribution of water-soluble chitosan in mice
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2022, Current Opinion in Chemical BiologyCitation Excerpt :This is of particular importance for exciting applications like alginate-based hydrogels for immunoisolation of islets of Langerhans, as a potential cure for type I diabetes [68]. Chitosan is biocompatible in many situations and toward many tissues, and biodegrades both in vivo [69] and in the environment (environmental degradation slows as DS(Ac) decreases) [70]. Chitosan pKA is roughly 6, [71], thus it is significantly positively charged below pH 6 by protonation of the C-2 amines.
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