COMPARISON OF WEIGHT REDUCTION WITH METOPROLOL IN TREATMENT OF HYPERTENSION IN YOUNG OVERWEIGHT PATIENTS
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The Impact of Obesity on the Pharmacology of Medications Used for Cardiovascular Risk Factor Control
2015, Canadian Journal of CardiologyCitation Excerpt :Most studies were single-dose or short-term studies, limiting the conclusions that can be made regarding long-term therapy. These studies have examined agents ranging in lipophilicity from lipophilic (propranolol,23,24,39-42 metoprolol,43,44 nebivolol,41,45), intermediate (bisoprolol46), and hydrophilic (atenolol,43,47 sotalol24; Supplemental Table S1). There is considerable intrastudy variation in terms of the effect of obesity on different pharmacokinetic parameters.
Obesity and Hypertension: Mechanisms, Cardio-Renal Consequences, and Therapeutic Approaches
2009, Medical Clinics of North AmericaCitation Excerpt :The antihypertensive efficacy of beta blockers in obese patients remains controversial. Small studies have shown that metoprolol was not effective in controlling blood pressure,105 whereas atenolol showed a beneficial effect.106 Consequently, the classic beta blockers are not recommended in obese patients for the control of blood pressure.
Obesity in Hypertension
2007, Hypertension: A Companion to Braunwald's Heart DiseaseControversies in hypertension
2006, LancetCitation Excerpt :Nevertheless, such calorie-reduced diets might (if adhered to) modify cardiovascular risk factors, including blood-pressure reduction. Notably, in two studies, diet combined with sodium restriction successfully reduced blood pressure, with a greater decrease at 21 weeks19 than at 52 weeks.20 Orlistat treatment for 4 years, together with lifestyle modifications, reduced bodyweight by 5% and blood pressure by 4·9/2·6 mm Hg (from initial values of 130·8/82·0 mm Hg), compared with a fall of 3·5/1·9 mm Hg with lifestyle alone (p<0·01).21
Nonpharmacologic interventions for reducing blood pressure in adults with prehypertension to established hypertension
2020, Journal of the American Heart AssociationPharmacotherapeutic strategies for treating hypertension in patients with obesity
2018, Expert Opinion on Pharmacotherapy
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Present address: Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Heart Lung and Blood Institute, National Institutes of Health, Maryland, USA.