Elsevier

The Lancet

Volume 392, Issue 10152, 22–28 September 2018, Pages 1072-1088
The Lancet

Health Policy
NCD Countdown 2030: worldwide trends in non-communicable disease mortality and progress towards Sustainable Development Goal target 3.4

https://doi.org/10.1016/S0140-6736(18)31992-5Get rights and content

Summary

The third UN High-Level Meeting on Non-Communicable Diseases (NCDs) on Sept 27, 2018, will review national and global progress towards the prevention and control of NCDs, and provide an opportunity to renew, reinforce, and enhance commitments to reduce their burden. NCD Countdown 2030 is an independent collaboration to inform policies that aim to reduce the worldwide burden of NCDs, and to ensure accountability towards this aim. In 2016, an estimated 40·5 million (71%) of the 56·9 million worldwide deaths were from NCDs. Of these, an estimated 1·7 million (4% of NCD deaths) occurred in people younger than 30 years of age, 15·2 million (38%) in people aged between 30 years and 70 years, and 23·6 million (58%) in people aged 70 years and older. An estimated 32·2 million NCD deaths (80%) were due to cancers, cardiovascular diseases, chronic respiratory diseases, and diabetes, and another 8·3 million (20%) were from other NCDs. Women in 164 (88%) and men in 165 (89%) of 186 countries and territories had a higher probability of dying before 70 years of age from an NCD than from communicable, maternal, perinatal, and nutritional conditions combined. Globally, the lowest risks of NCD mortality in 2016 were seen in high-income countries in Asia-Pacific, western Europe, and Australasia, and in Canada. The highest risks of dying from NCDs were observed in low-income and middle-income countries, especially in sub-Saharan Africa, and, for men, in central Asia and eastern Europe. Sustainable Development Goal (SDG) target 3.4—a one-third reduction, relative to 2015 levels, in the probability of dying between 30 years and 70 years of age from cancers, cardiovascular diseases, chronic respiratory diseases, and diabetes by 2030—will be achieved in 35 countries (19%) for women, and 30 (16%) for men, if these countries maintain or surpass their 2010–2016 rate of decline in NCD mortality. Most of these are high-income countries with already-low NCD mortality, and countries in central and eastern Europe. An additional 50 (27%) countries for women and 35 (19%) for men are projected to achieve such a reduction in the subsequent decade, and thus, with slight acceleration of decline, could meet the 2030 target. 86 (46%) countries for women and 97 (52%) for men need implementation of policies that substantially increase the rates of decline. Mortality from the four NCDs included in SDG target 3.4 has stagnated or increased since 2010 among women in 15 (8%) countries and men in 24 (13%) countries. NCDs and age groups other than those included in the SDG target 3.4 are responsible for a higher risk of death in low-income and middle-income countries than in high-income countries. Substantial reduction of NCD mortality requires policies that considerably reduce tobacco and alcohol use and blood pressure, and equitable access to efficacious and high-quality preventive and curative care for acute and chronic NCDs.

Introduction

Non-communicable diseases (NCDs) are the leading causes of ill health in the world and account for seven of ten worldwide deaths.1, 2 NCD mortality is higher in low-income and middle-income countries, and, at least in high-income countries, in people with lower socioeconomic status,3, 4, 5 making NCDs an important obstacle to reducing global and national health inequalities.6

Following the first UN High-Level Meeting on the prevention and control of NCDs in 2011, WHO member states committed to reduce, by 2025, mortality from four NCDs (cancers, cardiovascular diseases, chronic respiratory diseases, and diabetes; referred to as NCD4 hereafter) in people aged 30–70 years by 25% relative to their rates in 2010 (termed the 25 × 25 target). NCDs are also included in Sustainable Development Goal (SDG) target 3.4, to “by 2030 reduce by one third premature mortality from non-communicable diseases through prevention and treatment and promote mental health and well-being”. The indicator used to measure progress in reducing premature NCD mortality is the same as the 25 × 25 target, and suicide mortality is used as a tracer indicator for mental health.

2018 is an important year for action on NCDs,7 with the third UN High-Level Meeting on NCDs in September of this year set to review global and national progress, and renew and enhance political commitment towards reducing NCD mortality. Supporting these deliberations and commitments requires data on how NCD mortality is changing in different countries, and on what interventions and policies can reduce their burden. NCD Countdown 2030 is an independent collaboration to inform policies that aim to reduce the worldwide burden of NCDs, and to ensure accountability towards this aim (panel 1). This first report from NCD Countdown 2030 examines the current worldwide status of mortality from NCDs and whether, based on recent trends, each country is expected to reduce mortality in line with SDG target 3.4. We also assess the importance of outcomes and age groups beyond those included in this target and its indicators, and discuss the implications for NCD policies.

Key messages

In all but about 20 countries, people have a higher risk of dying prematurely from non-communicable diseases (NCDs) than from communicable, maternal, perinatal, and nutritional conditions combined. The risk of dying from NCDs is highest in low-income and middle-income countries, especially in sub-Saharan Africa, for both sexes, and in central Asia and eastern Europe for men.

Progress towards Sustainable Development Goal (SDG) target 3.4 varies markedly across countries. At the current rates of decline in NCD mortality, SDG target 3.4 is expected to be achieved for women in 35 countries (19% of all countries) and men in 30 countries (16%). A further 50 countries (for women) and 35 countries (for men) could achieve the target with a slight acceleration in decline.

Mortality from the four NCDs included in SDG target 3.4 (cancers, cardiovascular diseases, chronic respiratory diseases, and diabetes) has stagnated or increased since 2010 among women in 15 and men in 24 countries. Another 86 countries (for women) and 97 (for men) are progressing too slowly, and need policies that substantially increase the rates of decline if they are to meet SDG target 3.4.

NCD deaths beyond the age range and causes of death included in SDG target 3.4 cause a larger mortality burden in low-income and middle-income countries than in high-income countries.

Substantial reduction of NCD mortality requires policies that considerably decrease tobacco and alcohol use and blood pressure, and that provide equitable access to efficacious and high-quality preventive and curative care for NCDs in the context of universal health coverage.

Section snippets

NCDs as a global health challenge

We used data on deaths from NCDs—including cancers; cardiovascular diseases; diabetes; endocrine, blood, and immune disorders; non-infectious respiratory, digestive (including liver), and genitourinary diseases; neurological conditions; mental and substance-use disorders; congenital anomalies; and sense organ, skin, musculoskeletal, and oral or dental conditions—by sex and age group for 186 countries and territories from the 2016 WHO Global Health Estimates (three countries or territories were

Current status of NCD mortality and progress towards SDG target 3.4

Figure 3A maps the probability of dying from NCD4 between exactly 30 years and exactly 70 years of age in the absence of competing causes of death (the indicator used to measure progress towards SDG target 3.4) in 2016. SDG target 3.4 is calculated in the absence of competing causes of death so that it measures only the risk of dying from the causes of interest (NCD4).13 In addition, SDG target 3.4 uses deaths from suicides as a tracer for mental health (panel 2, figure 4).

For women, the

NCD mortality beyond SDG target 3.4

The WHO 25 × 25 target and SDG target 3.4 both refer to deaths from NCD4 between exactly 30 years and 70 years of age. In 2016, there were 12·5 million deaths from NCD4 in this age group. However, the indicator used for these targets excludes other NCDs and age groups.

First, an estimated 1·7 million NCD deaths in people younger than 30 years of age (4% of all 40·5 million NCD deaths; 18% of all 9·3 million deaths in this age group) are not included in the indicator. Of these, about 0·6 million

Which NCDs are driving the declines in mortality?

Figure appendix 2 shows the contribution of changes in major disease clusters to the overall decline in the probability of dying from NCDs between birth and 80 years of age. In high-income countries, cancers have emerged as important contributors to the overall decrease in NCD mortality alongside cardiovascular diseases, which have declined for decades,42, 43, 44 and diabetes, the death rates of which are now declining.45 In central and eastern Europe, where cardiovascular disease mortality is

Measurement and monitoring gaps

High-quality data on the numbers and causes of death, risk factors, preventive and curative interventions, and health-system infrastructure, use, and quality, are essential to monitor progress towards NCD targets, as well as their determinants and interventions.47 In particular, death registration with medical certification and International Classification of Diseases coding of the causes of death is the preferred source of information for monitoring mortality. If too few deaths are registered,

Actions to accelerate reductions in NCD mortality

Our independent evaluation shows that NCD mortality is decreasing in most countries, but the pace of decline varies substantially, even among countries in the same region. Many countries in high-income regions of Asia-Pacific, Australasia, North America, and western Europe, and in central and eastern Europe, and some other low-income and middle-income countries are on track for achieving SDG target 3.4, and more countries could achieve the target if they implement policies that slightly

Financing, priority setting, and implementation

Low-income and some middle-income countries face a substantial financing gap for the implementation of NCD programmes,112 especially for high-quality NCD care in the context of universal health coverage. The WHO Independent High-Level Commission on NCDs has recommended that higher percentages of national budgets are allocated to health, and that, within health, a higher percentage is allocated to NCDs and mental health, financed partly through higher taxes on tobacco and alcohol.10 The

References (120)

  • P Lloyd-Sherlock et al.

    A premature mortality target for the SDG for health is ageist

    Lancet

    (2015)
  • V Kontis et al.

    Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble

    Lancet

    (2017)
  • EW Gregg et al.

    Trends in cause-specific mortality among adults with and without diagnosed diabetes in the USA: an epidemiological analysis of linked national survey and vital statistics data

    Lancet

    (2018)
  • C AbouZahr et al.

    Civil registration and vital statistics: progress in the data revolution for counting and accountability

    Lancet

    (2015)
  • K Kuulasmaa et al.

    Estimation of contribution of changes in classic risk factors to trends in coronary-event rates across the WHO MONICA Project populations

    Lancet

    (2000)
  • G Danaei et al.

    Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors

    Lancet

    (2005)
  • D Zaridze et al.

    Alcohol and cause-specific mortality in Russia: a retrospective case-control study of 48,557 adult deaths

    Lancet

    (2009)
  • D Zaridze et al.

    Alcohol and mortality in Russia: prospective observational study of 151,000 adults

    Lancet

    (2014)
  • H Tunstall-Pedoe et al.

    Estimation of contribution of changes in coronary care to improving survival, event rates, and coronary heart disease mortality across the WHO MONICA Project populations

    Lancet

    (2000)
  • P Asaria et al.

    Acute myocardial infarction hospital admissions and deaths in England: a national follow-back and follow-forward record-linkage study

    Lancet Public Health

    (2017)
  • M Plummer et al.

    Global burden of cancers attributable to infections in 2012: a synthetic analysis

    Lancet Glob Health

    (2016)
  • J Pearson-Stuttard et al.

    Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment

    Lancet Diabetes Endocrinol

    (2018)
  • F Bray et al.

    Global cancer transitions according to the human development index (2008–2030): a population-based study

    Lancet Oncol

    (2012)
  • H Gelband et al.

    Costs, affordability, and feasibility of an essential package of cancer control interventions in low-income and middle-income countries: key messages from Disease Control Priorities, 3rd edition

    Lancet

    (2016)
  • V Kontis et al.

    Regional contributions of six preventable risk factors to achieving the 25 × 25 non-communicable disease mortality reduction target: a modelling study

    Lancet Glob Health

    (2015)
  • V Kontis et al.

    Contribution of six risk factors to achieving the 25 × 25 non-communicable disease mortality reduction target: a modelling study

    Lancet

    (2014)
  • C Allemani et al.

    Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)

    Lancet

    (2015)
  • P Asaria et al.

    Chronic disease prevention: health effects and financial costs of strategies to reduce salt intake and control tobacco use

    Lancet

    (2007)
  • P Anderson et al.

    Effectiveness and cost-effectiveness of policies and programmes to reduce the harm caused by alcohol

    Lancet

    (2009)
  • S Gravely et al.

    Implementation of key demand-reduction measures of the WHO Framework Convention on Tobacco Control and change in smoking prevalence in 126 countries: an association study

    Lancet Public Health

    (2017)
  • LS Adair et al.

    Associations of linear growth and relative weight gain during early life with adult health and human capital in countries of low and middle income: findings from five birth cohort studies

    Lancet

    (2013)
  • CG Victora et al.

    Maternal and child undernutrition: consequences for adult health and human capital

    Lancet

    (2008)
  • S Du et al.

    Understanding the patterns and trends of sodium intake, potassium intake, and sodium to potassium ratio and their effect on hypertension in China

    Am J Clin Nutr

    (2014)
  • H Ueshima et al.

    Declining trends in blood pressure level and the prevalence of hypertension, and changes in related factors in Japan, 1956–1980

    J Chronic Dis

    (1987)
  • Global health estimates 2016: deaths by cause, age, sex, by country and by region, 2000-2016

    (2018)
  • World health statistics 2018: monitoring health for the SDGs

    (2018)
  • M Ezzati et al.

    Acting on non-communicable diseases in low- and middle-income tropical countries

    Nature

    (2018)
  • T Boerma et al.

    Countdown to 2030: tracking progress towards universal coverage for reproductive, maternal, newborn, and child health

    Lancet

    (2018)
  • Time to deliver: report of the WHO Independent High-level Commission on Noncommunicable Diseases

    (2018)
  • WHO methods and data sources for country-level causes of death 2000–2016

    (2018)
  • SH Preston et al.

    Demography: measuring and modeling population processes

    (2001)
  • IM Tøllefsen et al.

    The reliability of suicide statistics: a systematic review

    BMC Psychiatry

    (2012)
  • AJ Ferrari et al.

    The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010

    PLoS One

    (2014)
  • Preventing suicide: a global imperative

    (2014)
  • MD Anestis et al.

    Suicide Rates and State Laws Regulating Access and Exposure to Handguns

    Am J Public Health

    (2015)
  • JJ Mann et al.

    Suicide prevention strategies: a systematic review

    JAMA

    (2005)
  • KD Kochanek et al.

    Mortality in the United States, 2016

    NCHS Data Brief

    (2017)
  • A Case et al.

    Rising morbidity and mortality in midlife among white non-Hispanic Americans in the 21st century

    Proc Natl Acad Sci USA

    (2015)
  • GK Singh et al.

    Widening rural-urban disparities in all-cause mortality and mortality from major causes of death in the USA, 1969–2009

    J Urban Health

    (2014)
  • Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants

    Lancet

    (2017)
  • Cited by (710)

    View all citing articles on Scopus

    Collaborators listed at end of paper

    View full text