CommentOptimisation of mass chemotherapy to control soil-transmitted helminth infection
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Cited by (42)
Measuring heterogeneities in soil-transmitted helminth transmission and control
2024, Trends in ParasitologyThe impact of seasonality on the dynamics and control of Ascaris lumbricoides infections
2018, Journal of Theoretical BiologyCitation Excerpt :Therefore, since the drugs are relatively inexpensive and often donated (www.who.int/neglected_diseases/en), entire communities at risk are often offered multiple rounds of treatment. However, the optimal strategy for delivering the most effective community-based treatments is still open to question (Anderson et al., 2012; 2015). Seasonal treatment has been evaluated for Schistosomiasis (Augusto et al., 2009), where the effect of treatment was found to be enhanced if administered during the low transmission season.
Measuring and modelling the effects of systematic non-adherence to mass drug administration
2017, EpidemicsCitation Excerpt :However, other programs are not achieving the expected goals, and so we are facing the question of why these “failures” are occurring and how better to measure the effectiveness of control programs. Mathematical modelling plays an important role in the design of MDA programs—who to treat, when to treat (Anderson et al., 2012, 2015; Coffeng et al., 2014, 2015; Gambhir and Pinsent, 2015; Gurarie et al., 2015; Irvine et al., 2015; Jambulingam et al., 2016; Liu et al., 2015; Singh and Michael, 2015; Stolk et al., 2015; Truscott et al., 2015; Winnen et al., 2002)—and in setting the ‘expected’ prevalence after a certain number of rounds, particularly for onchocerciasis (Tekle et al., 2016). Modelling studies have highlighted the importance of coverage (the proportion of the target population who are treated), with high coverage leading to more rapid declines in prevalence and sustained high coverage leading to the possibility of elimination (Okell et al., 2011; Slater et al., 2014).
Study design and baseline results of an open-label cluster randomized community-intervention trial to assess the effectiveness of a modified mass deworming program in reducing hookworm infection in a tribal population in southern India
2017, Contemporary Clinical Trials CommunicationsCitation Excerpt :Moreover, recent modeling-based estimates suggest that school-based deworming may have limited impact in interrupting the community transmission of STH infections, especially in places where hookworm predominates because most infection is harbored by adults [20]. The transmission of an infectious agent following drug treatment is a dynamic process, and is determined by many factors including treatment frequency, coverage and efficacy [21,22]. Suboptimal treatment may result in persistence of an untreated reservoir of transmission, thereby increasing the likelihood of reinfection [23] and the need for periodic treatments to interrupt transmission in endemic communities [24].
Studies of the Transmission Dynamics, Mathematical Model Development and the Control of Schistosome Parasites by Mass Drug Administration in Human Communities
2016, Advances in ParasitologyCitation Excerpt :Criteria are presented for elimination based on different levels of MDA coverage in school-aged children (SAC), between the ages of 5 and 14 years, and adults, who are defined as older than 15 years. The key questions that can be addressed in a quantitative manner by the use of transmission mathematical models that are examined in this paper can be summarized as follows (Anderson et al., 2012): For a given transmission level, how often should mass or targeted chemotherapy be administered to sustain infection prevalence and intensity below defined levels?