Caps in Eukaryotic mRNAs: Mechanism of Formation of Reovirus mRNA 5′-Terminal m7GpppGm-C
References (28)
- et al.
Cell
(1975) - et al.
Cell
(1975) - et al.
Cell
(1976) - et al.
JMB
(1975) - et al.
JBC
(1975) - et al.
JBC
(1976) - et al.
JBC
(1975) - et al.
JBC
(1975) - et al.
Cell
(1976) - et al.
Virology
(1975)
Cell
PNAS
Nature
PNAS
Cited by (19)
Silencing and complementation of reovirus core protein μ2: Functional correlations with μ2-microtubule association and differences between virus- and plasmid-derived μ2
2007, VirologyCitation Excerpt :Combining these results, our working hypothesis is that, within infected cells, the μ2 protein is normally assembled into progeny particles, where its NTPase function is required for genome replication and/or secondary transcription, as well as for primary transcription once progeny virions are released and move on to infect new cells. In the case of transcription, the RTPase activity of μ2 may be instead or additionally required in 5′-capping of the plus-strand RNAs, i.e., for generating a diphosphorylated 5′ end on each RNA to which GMP is then linked by the guanylyltransferase λ2 (Cleveland et al., 1986; Furuichi et al., 1976; Mao and Joklik, 1991). Having successfully applied the siRNA approach, we are now in stronger position to perform a combination of future studies in vitro and in vivo to dissect the different roles of μ2 during infection.
Nucleoside and RNA Triphosphatase Activities of Orthoreovirus Transcriptase Cofactor μ2
2004, Journal of Biological ChemistryCitation Excerpt :RTPase Activity of wt μ2—The capacity of wt μ2 to release the γ-phosphate from an NTP led us to hypothesize that μ2 may also release the 5′ γ-phosphate from an RNA molecule. mORV cores mediate such an RTPase activity, which yields a diphosphorylated RNA 5′ end (11, 49) for linkage to GMP by the λ2-associated guanylyltransferase (4, 11, 14, 15, 17, 18), as part of the mRNA capping process. The RTPase activity has been previously attributed to the λ1 shell protein (12).
From the messenger RNA saga to the transcriptome era
2003, Comptes Rendus - BiologiesAntibodies Specific for Modified Nucleosides: An Immunochemical Approach for the Isolation and Characterization of Nucleic Acids
1980, Progress in Nucleic Acid Research and Molecular BiologyThe structural properties and identification of insect viruses
1979, Advances in Virus ResearchTranslation of plant virus messenger rnas
1979, Advances in Virus Research