Long-term results of renal transplantation using organs from non-heart-beating donors
Section snippets
Patients and methods
Between 1992 and 1998, 72 NHBD and 192 HBD kidney transplants were performed. The retrieval procedures for NHBD and HBD were standard, and the kidneys were cold stored with Marshall’s hyperosmolar citrate solution. NHBD recipients received a lower initial dose of calcineurin inhibitor to reduce the drug toxicity to the ischaemically insulted organs. Major matching criteria were cold ischaemic time, HLA DR mismatch, donor age, and whether the graft was a first or retransplant. Minor criteria
Results
The 72 kidneys from NHBD accounted for 24% of the renal transplants performed in Leicester during the study, and 105 of the 192 HBD kidneys were matched to NHBD transplants according to the criteria above. There were no differences between groups in recipient age, sex, or major matching criteria (continuous variables: student’s t test, discrete: χ2).
Log rank analysis of Kaplan-Meier survival curves revealed no difference between the groups. One-, 3-, and 5-year patient and graft survival were
Discussion
The survival of NHBD kidney transplants is comparable with those from HBD. DGF is much more prevalent among NHBD transplants than their HBD counterparts, however PNF was no different. The results of this study demonstrate that NHBD may substantially increase the availability of kidneys for transplantation with excellent results.
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