Selective and efficient synthesis of di-, tri- and tetrasubstituted 1, 10-phenanthrolines

doi:10.1016/S0040-4039(99)00501-8

Tetrahedron Letters

Volume 40, Issue 17, 23 April 1999, Pages 3395-3396

https://doi.org/10.1016/S0040-4039(99)00501-8 Get rights and content

Abstract

A general synthetic procedure for the preparation of multisubstituted phenanthrolines is presented. Bromination of 1, 10-phenanthroline at the 3 and 8 positions, followed by Suzuki coupling reaction and subsequent methylation afford the di-, tri and tetra- substituted phenanthrolines in good yields. These phenanthroline derivatives are useful building blocks in the construction of highly sophisticated molecular architectures.

1, 10-Phenanthrolines1–4b have been synthesized in good yields.

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Selective and efficient synthesis of di-, tri- and tetrasubstituted 1, 10-phenanthrolines

Abstract

Tetrahedron Lett.

Angew. Chem. Int. Ed.

Inorg. Chem.

Angew. Chem. Int. Ed.