A general and efficient solid phase synthesis of quinazoline-2,4-diones
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Recent advances in application of amino acids: Key building blocks in design and syntheses of heterocyclic compounds
2015, Advances in Heterocyclic ChemistryCitation Excerpt :A wide variety of N,N-disubstituted hydantoin libraries have been synthesized using derivatives of AAs, aromatic aldehydes, and isocyanates (97TL4603). Various hydantoins have been synthesized using resin-bound N-alkylated glycine residues (98TL3589) via treatment of a resin-bound diamino acid containing a dipeptide with carbonyl diimidazole or triphosgene (98TL8199) by preparation of resin-attached hydrazino acid precursors (98TL5135) through direct conversion of Fmoc-protected dipeptides (99TL2493). The coupling between Wang resin 94 and amino acid derivative 93 gave almost a quantitative yield (>95%) of the resin-linked AA 95.
A convenient procedure for the solid-phase synthesis of hydroxamic acids on PEGA resins
2011, Tetrahedron LettersChemical fixation of CO<inf>2</inf>: efficient synthesis of quinazoline-2,4(1H, 3H)-diones catalyzed by guanidines under solvent-free conditions
2010, TetrahedronCitation Excerpt :Organic guanidines, which are categorized as organic superbases with ease of structural modification,17 are efficient organic catalysts for the types of base induced reactions in organic synthesis.18 Particularly, guanidines could interact with CO2 through a kinetically reversible way, leading to CO2 fixation.19 As our continuous interest in chemical fixation of CO2,20 we developed an efficient approach for the synthesis quinazoline-2,4(1H, 3H)-diones from CO2 and 2-aminobenzonitriles catalyzed by low amounts of organic guanidines without the need of any additional solvent.
General methodology for solid-phase synthesis of N-alkyl hydroxamic acids
2004, Tetrahedron Letters