Elsevier

Tetrahedron Letters

Volume 44, Issue 1, 1 January 2003, Pages 81-84
Tetrahedron Letters

A general method for the formation of diaryl selenides using copper(I) catalysts

https://doi.org/10.1016/S0040-4039(02)02480-2Get rights and content

Abstract

We report a mild, palladium-free synthetic protocol for the cross coupling reaction of aryl iodides and phenyl selenol using 10 mol% CuI/neocuproine, NaOt-Bu or K2CO3 as base, in toluene, at 110°C. Using this protocol, we show that a variety of diaryl selenides can be synthesized in good yields from commercially available aryl iodides.

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Acknowledgments

The University of Massachusetts, Amherst start-up funds provided the financial support for this research. D.V. gratefully acknowledges a Camille and Henry Dreyfus New Faculty Award and an NSF CAREER Award (CHE-0134287).

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