The first total synthesis of iPF4α-VI and its deuterated analog
Stereospecific syntheses of DHA-derived isoprostane iPF4α-VI and its d4 analog are reported.
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Acknowledgements
We wish to acknowledge the NIH for support under Grants DK-44730 (J.R.), HL-54500, and HL-62250 (G.A.F.); the AHA for support under Grant 0030211 (D.P.); and the NSF for an AMX-360 NMR instrument (Grant CHE-90-13145).
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2006, Journal of Lipid ResearchCitation Excerpt :To aliquots (1 ml) of the supernatant fraction were added 1 ml of 100 mM phosphate buffer, pH 7.4, containing 50 mM KCl, 7.2 mM MgCl2, 8 mM ATP, 1 mM CoA, 4 mM l-carnitine, and 4 mM NAD+. Either nPF4α-VI [final concentration, 20 μM; synthesized as described previously (21)] or iPF3α-VI (final concentration, 20 μM) was added, and the mixture was incubated for 90 min at 37°C. The incubations were stopped by the addition of 1 vol of MeOH and cooled on ice.
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