New chemistry of amines. 2. A convenient synthesis of phosphotriesters from phosphoramidates

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Abstract

N-alkyl diethylphosphoramidates can be nitrosated at room temperature, whereupon a spontaneous rearrangement occurs with loss of nitrogen to afford alkyl diethylphosphates in good yield.

Amines can be converted to phosphoesters by a new rearrangement

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Part 2 in the series, “New Chemistry of Nitrosoamides.” For Part 1, see ref. 8.