Structures of albanols a and b, two novel phenols from Morus alba bark
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Diastereodivergent synthesis of chromeno[2,3-b]chromenes by tuning all of the reactivity centers of isocyanoacetate
2022, Chemical CommunicationsUpdated ethnobotanical notes, phytochemistry and phytopharmacology of plants belonging to the genus Morus (Family: Moraceae)
2022, Phytomedicine PlusCitation Excerpt :White Mulberry (Morus alba), blackberry (Morus nigra), and red berry (Morus rubra) are the most commonly found mulberry varieties among them (Ercisli and Orhan, 2007). Various phytoconstituents are present in this genus, including Albanol (Rao et al., 1983), Amyrin (Deshpande and PV, 1976), Mulberrin (Deshpande et al., 1968), Morin, Deoxynojirimycin (DNJ) (Zafar et al., 2013), Epicatechin (Deepa et al., 2013), β-sitosterol (Kulkarni et al., 1970), Gallic acid (Ghareeb et al., 2016), Vanillic acid (Hanif and Singh, 2012), Rutin, Kaempferol (Dat et al., 2010), Oxyresveratrol (Chen et al., 2013), Quercetin (Deshpande, 1975), Flavone A, B and C (Ali and Ali, 2013; Deshpande and PV, 1974), etc. Mulberry contains numerous biological functions, such as anti-thrombotic (Yamamoto et al., 2006), antioxidant (Kamiloglu et al., 2013), anti-obesity (Khalifa et al., 2018), anti-inflammatory (He et al., 2018), anti-cancer (Cho et al., 2017)and neuroprotective activity (Kawvised et al., 2017).
Synthesis and antiplasmodial evaluation of novel chromeno[2,3-b]chromene derivatives
2012, Bioorganic and Medicinal ChemistryCitation Excerpt :Similarly, a systematic study performed on plants belonging to the Moraceae family showed the presence of antimicrobial activity in the extract of Sorocea ilicifolia, from which a number of phenolic components were isolated. One among them was the ketalized Diels–Alder type adduct, named sorocein L 4.16 The strategies employed for the synthesis of this ring system include the condensation of dimethylol ketones with 2-naphthol using Amberlyst-15 as catalyst,17 reaction of phenolic Mannich bases with α-chloroacrylonitrile involving [4+2] cycloaddition18 and the Diels–Alder cylcoaddition reactions of o-quinone methides, generated from 4H-1,2-benzoxazines with various dienophiles.19
Bioactive compounds from the genus broussonetia
2003, Studies in Natural Products ChemistryCitation Excerpt :Several synthetic aromatase-inhibitory drugs have been developed, including aminoglutethimide, substrate androstenedione derivatives, imidazoles, and triazoles [63-65]. From the active extract of B. papyrifera were isolated several aromatase inhibitors with IC50 values in the range 0.1-31.1 μM, inclusive of broussonin A (29) [66], 3′-[γ-hydroxymethyl-(E)-γ-methylallyl]-2,4,2′,4′-tetrahydroxychalcone 11′-O-coumarate (33) [41], isogemichalcone C (34) [41], 2,4,2′,4′-tetrahydroxy-3′-prenylchalcone (35) [67], (2S)-abyssinone II (38) [68], (2S)-2′,4′-dihydroxy-2ʺ-(1-hydroxy-1-methylethyl)-dihydrofiiro[2,3-h]flavanone (39) [41], (2S)-euchrenone a7 (40) [69], (2S)-naringenin (41) [70], (2S)-5,7,2′,4′-tetrahydroxyflavanone (42) [71], 5,7,2′,4′-tetrahydroxy-3-geranylflavone (43) [41], broussoflavonol F (45) [50], isolicoflavonol (47) [72], albanol A (49) [73], demethylmoracin I (51) [41], moracin N (53) [74]. Of these aromatase inhibitors, five of the compounds were new (33, 34, 39, 43, 51), and details of structure elucidation of 33, 34, and 43 are presented as examples in the following two paragraphs.
Chemistry and Biosynthesis of Natural Diels-Alder Type Adducts from Moraceous Plants
1995, Studies in Natural Products ChemistryMulberry Diels–Alder-type adducts: isolation, structure, bioactivity, and synthesis
2022, Natural Products and Bioprospecting