Factors affecting stereochemical control in directed homogeneous hydrogenation of α-hydroxyalkylacrylates

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Abstract

The degree of asymmetric induction observed in hydrogenation of menthyl 3-hydroxy-2-methylenebutyrates catalysed by DIPAMP-Rh+ complexes is strongly dependent on the configuration of the menthyl group. For a related methyl ester syn as well as anti-reduction product is formed with high enantioselection.

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