Elsevier

Tetrahedron Letters

Volume 41, Issue 44, 28 October 2000, Pages 8425-8429
Tetrahedron Letters

Stereoselective construction of quaternary carbon centers by three component coupling reactions

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Abstract

TiCl4 promoted coupling reactions of pyruvates with vinyl ethers such as 3,4-dihydro-2H-pyran or 2,3-dihydrofuran constructed quaternary carbon centers stereoselectively.

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Acknowledgements

Financial support for this work was provided by the National Institutes of Health. The authors thank Professors Martin Newcomb and Vladimir Gevorgyan for helpful discussions.

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