α-Amino-α-trifluoromethyl-phenylacetonitrile: A potential reagent for 19F NMR determination of enantiomeric purity of acids
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α-Amino-α-trifluoromethyl-phenylacetonitrile, 1, has been converted to the mixture of diastereomeric amides (2). The 19F Chemical shift differences (Δδ = δRR − δRS) for a series of these diastereomers have been studied for the determination of enantiomeric purity of chiral acids (R1COOH). R1- = PhCH(OMe)-, PhCH(OCOMe)-, Ph CH(C2H5-, PhCH(t-Bu)-, Ph(OMe)(CF3)-, C2H5CH(CH3)- etc.
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On leave from the Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Copyright © 1993 Published by Elsevier Ltd.