Lung physiological and metabolic changes in lambs with congenital diaphragmatic hernia after administration of prenatal maternal corticosteroids☆,☆☆
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Cited by (16)
Pathophysiology of persistent pulmonary hypertension of the newborn-cellular basis and lessons from animal studies
2018, Hemodynamics and Cardiology: Neonatology Questions and ControversiesPulmonary arteriole muscularization in lambs with diaphragmatic hernia after combined tracheal occlusion/glucocorticoid therapy
2007, American Journal of Obstetrics and GynecologyCitation Excerpt :In fetal sheep with severe DH, intravenous infusions of cortisol between 133 and 135 days of gestation increased arterial PO2 (DH group, 20 ± 3 mm Hg; DH-cortisol group, 38 ± 6 mm Hg) and dynamic lung compliance and reduced septal wall-thickness.44 Kapur et al45 also reported that lung compliance was increased in lambs with DH that underwent prenatal glucocorticoid therapy, although improvement in gas exchange was not observed. In a report of 3 infants with DH that underwent repetitive prenatal glucocorticoid-therapy, Ford et al46 concluded that “prolonged steroid administration over 10 weeks of pregnancy may have contributed to ease of ventilation, absence of pulmonary hypertension, and survival.”
Antenatal vitamin A decreases ventilation-induced lung injury in the lamb model of congenital diaphragmatic hernia
2006, Asian Journal of SurgeryCorticosteroids for fetuses with congenital diaphragmatic hernia: Can we show benefit?
2006, Journal of Pediatric SurgeryLung function in lambs with diaphragmatic hernia after reversible fetal tracheal occlusion
2004, Journal of Pediatric SurgeryThe CDH study group and advances in the clinical care of the patient with congenital diaphragmatic hernia
2004, Seminars in Perinatology
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Presented at the 45th Annual International Congress of the British Association of Paediatric Surgeons, Bristol, England, July 21–24, 1998.
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This work was supported by a grant from The National Institutes of Health (HL 49977).