Contractile properties of intralobar pulmonary arteries and veins in the fetal lamb model of congenital diaphragmatic hernia☆,☆☆
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Cited by (21)
Pathophysiology of persistent pulmonary hypertension of the newborn-cellular basis and lessons from animal studies
2018, Hemodynamics and Cardiology: Neonatology Questions and ControversiesCongenital diaphragmatic hernia: Searching for answers
2005, American Journal of SurgeryCitation Excerpt :Karamanoukian et al [82] observed similar staining patterns for eNOS in the main pulmonary arteries of CDH and control lambs. This group also reported no difference in the responses of isolated fourth-generation pulmonary arterioles from lambs with surgically created CDH to eNOS activation or to inhibition of cyclic GMP degradation (the effector molecule for nitric oxide [NO]) [83]. Similarly, Thébaud et al [84] observed no differences in pulmonary blood flow or pulmonary vascular resistance responses in intact fetal lambs with or without CDH to activators of the NO-cyclic guanosine monophosphate (NO-cGMP) pathway.
Pulmonary vasodilator therapy in congenital diaphragmatic hernia: Acute, late, and chronic pulmonary hypertension
2005, Seminars in PerinatologyShort-term tracheal occlusion corrects pulmonary vascular anomalies in the fetal lamb with diaphragmatic hernia
2000, SurgeryCitation Excerpt :In the nitrofen rat model of diaphragmatic hernia, North et al19 have shown a decreased expression of messenger RNA for endothelial nitric oxide synthase compared with normal control subjects. Similar findings have been reported in a fetal lamb model of diaphragmatic hernia-related pulmonary hypoplasia.20 Surfactant production, which is known to be deficient in diaphragmatic hernia,21 may have a direct effect on pulmonary vasodilation as well.4
Pulmonary vascular biology during neonatal transition
1999, Clinics in PerinatologyLamb models of pulmonary hypertension
2010, Drug Discovery Today: Disease ModelsCitation Excerpt :When the lambs are delivered at term gestation, lung alveolarization is disrupted, and there is a decrease in the total size of the pulmonary vascular bed, a decrease in the number of vessels per unit lung, and an increase in the muscularization of the pulmonary arterial tree compared to controls [30]. These findings bear a striking similarity to human disease and are associated with functional abnormalities of NO-cGMP signaling [31,32]. Recent studies indicate that these lambs have significant alterations in pulmonary hemodynamics before delivery, as well as significant pulmonary hypertension after delivery and ventilation, with pulmonary arterial approaching aortic pressure.
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Presented at the 29th Annual Meeting of the Canadian Association of Pediatric Surgeons, Banff, Alberta, Canada, October 4–6, 1997.
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This work was supported in part by The American Lung Association, The Women and Children's Health and Research Foundation, NIH HL 36543, NIH HL 49977, NIH HL 54705, and by the U.S. Surgical Corporation, Norwalk, CT.