Studies on mechanisms of calcium channel modulators
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S- and C-nucleosidoquinazoline as new nucleoside analogs with potential analgesic and anti-inflammatory activity
2009, European Journal of Medicinal ChemistryCitation Excerpt :Adult male Sprague-Dawley rats, weighing 150–200 g were used for anti-inflammatory and ulcerogenic activity, whereas Swiss albino mice of both sex weighing 25–30 g were used for analgesic activity. International principles and local regulations concerning the care and used of laboratory animals were taken into account [17]. The animals had free access to standard commercial diet and water adlibitum and were kept in rooms maintained at 22 ± 1 °C with 12 h light dark cycle.
Antimicrobial studies of some novel quinazolinones fused with [1,2,4]-triazole, [1,2,4]-triazine and [1,2,4,5]-tetrazine rings
2009, European Journal of Medicinal ChemistryCitation Excerpt :The pharmacodynamic versatility of 4-quinazolinone moiety has been documented not only in many of its synthetic derivatives but also in several naturally occurring alkaloids isolated from animals, families of plant kingdoms and from microorganism [1–3]. These isolated quinazolinones derivatives were found to have wide range of biological properties including anti-tumour, sedative, analgesic, antidiabetic, antibacterial, anti-inflammatory, antifungal and anticancer [4–10]. In addition, characterization of potential N-methyl-d-aspartate (NMDA) and cholecystokinin antagonists II-lipophilicity studies on quinazolinones are also documented [11].
Synthesis and biological properties of 4-(3H)-quinazolone derivatives
2007, European Journal of Medicinal ChemistryCitation Excerpt :Quinazolone and their derivatives are building block for approximately 150 naturally occurring alkaloids isolated from a number of families of the plant kingdom, from microorganisms and animals [1–4] and are now known for a wide range of biological properties including hypnotic, sedative, analgesic, anticonvulsant, antibacterial, antidiabetic, anti-inflammatory, anti-tumor and several other useful and interesting properties [5–13]. In addition, some derivatives are calcium antagonists and share the common property of interfering with the influx of extracellular calcium via the calcium L channel [14]. Recently quinozolone chemistry has got new direction due to some resemblance with folic acid [15–17].
Synthesis and pharmacological study of novel pyrido-quinazolone analogues as anti-fungal, antibacterial, and anticancer agents
2006, Bioorganic and Medicinal Chemistry LettersEffect of glucose on endothelin-1-induced calcium transients in cultured bovine retinal pericytes
1999, Journal of Biological ChemistryLipids and cardiac arrhythmia
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