Glutamatergic antagonists do not attenuate light-induced Fos protein in rat intergeniculate leaflet

doi:10.1016/S0006-8993(98)00911-1

Brain Research

Volume 810, Issues 1–2, 9 November 1998, Pages 264-268

https://doi.org/10.1016/S0006-8993(98)00911-1 Get rights and content

Abstract

Photic information that entrains circadian rhythms is transmitted to the suprachiasmatic nucleus (SCN) from the retina and from the retinorecipient intergeniculate leaflet (IGL). Expression of light-induced Fos protein in SCN neurons is correlated with the effectiveness of such light to induce phase shifts, and is prevented by pretreatment with glutamate receptor antagonists that prevent phase shifts as well. In the present study we demonstrate that treatments with N-methyl-d-aspartate (NMDA) and non-NMDA receptor antagonists prior to light pulses during the subjective night have no effect on light-induced Fos immunoreactivity (Fos-IR) in IGL neurons despite attenuating Fos-IR in the SCN. Transmission of photic information along retinogeniculate and retinohypothalamic pathways appears to be mediated by different mechanisms.

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Acknowledgements

This work was supported by grants from the Medical Research Council of Canada, the Natural Sciences and Engineering Research Council of Canada, and the Fonds pour la Formation de Chercheurs et l'Aide à la Recherche (Québec).

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The primary mammalian circadian clock resides in the suprachiasmatic nucleus (SCN), a recipient of dense retinohypothalamic innervation. In its most basic form, the circadian rhythm system is part of the greater visual system. A secondary component of the circadian visual system is the retinorecipient intergeniculate leaflet (IGL) which has connections to many parts of the brain, including efferents converging on targets of the SCN. The IGL also provides a major input to the SCN, with a third major SCN afferent projection arriving from the median raphe nucleus. The last decade has seen a blossoming of research into the anatomy and function of the visual, geniculohypothalamic and midbrain serotonergic systems modulating circadian rhythmicity in a variety of species. There has also been a substantial and simultaneous elaboration of knowledge about the intrinsic structure of the SCN. Many of the developments have been driven by molecular biological investigation of the circadian clock and the molecular tools are enabling novel understanding of regional function within the SCN. The present discussion is an extension of the material covered by the 1994 review, “The Circadian Visual System.”
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Citation Excerpt :
Studies characterizing immediate early gene induction in the circadian system have not been limited to the SCN. The IGL has been implicated in both photic and non-photic regulation of circadian rhythms [11,37–39], and it was found previously that induction of c-Fos expression in the IGL is regulated by mechanisms different from those regulating c-Fos expression in the SCN [1,10,12]. However, little is known about the circadian and photic regulation of JunB expression in the IGL.
The immediate-early genes c-Fos and JunB are implicated in light signaling within the suprachiasmatic nucleus (SCN), the mammalian circadian clock. Light induces phase-dependent expression of c-Fos and JunB within the retinorecipient SCN. In the absence of light, rhythmic expression of these genes has been observed in the dorsal region of the SCN with peak expression observed near dawn. The present study examined the pattern of induction of c-Fos and JunB in the SCN and intergeniculate leaflet (IGL) of rats housed in constant conditions, under light–dark cycles, or in dark-adapted light-stimulated animals. In contrast with previous studies, no evidence of expression of c-Fos and JunB was observed within the dorsal SCN, regardless of circadian time. Strain differences could account for the absence of rhythmic JunB expression, whereas the use of a monoclonal anti-c-Fos antibody in the present study may account for the absence of dorsal SCN c-Fos staining. The profile of light-induced c-Fos and JunB expression was consistent with previous observations. In the SCN, light-induced expression of c-Fos and JunB was phase dependent, whereas in the IGL light-induced both c-Fos and JunB regardless of circadian time.
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Short communicationGlutamatergic antagonists do not attenuate light-induced Fos protein in rat intergeniculate leaflet

Abstract

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Acknowledgements

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Short communication
Glutamatergic antagonists do not attenuate light-induced Fos protein in rat intergeniculate leaflet