Biophysical Journal
Volume 54, Issue 6, December 1988, Pages 1165-1168
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Research Article
Rate-amplitude correlation from single-channel records. A hidden structure in ion channel gating kinetics?

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Lifetime probability density functions from single-channel recording are usually assumed to follow a multiexponential form. The amplitudes and rate constants for each exponential component are presumed to be independent. We have explored this assumption and have found a correlation between the amplitudes and the rate constants in certain cases. We examine this correlation and the possibility that other functional forms may also properly describe these distribution functions.

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