Degradation of I125-labelled serum low density lipoprotein in normal and estrogen-treated male rats

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Summary

Experiments were performed to determine the site of degradation of radioiodinated serum low density lipoprotein (I125-LDL). Estrogen treatment, which was found to result in near absence of LDL in adult male rats, was employed for comparison with the normal catabolic system. Differences were noted between normal and estrogen-treated rats regarding kinetics of disappearance of I125-LDL from the serum. Insitu perfused livers from normal rats were found to take up and degrade I125-LDL; both processes were accelerated in perfused livers from estrogen-treated rats. The liver is proposed as a major site of I125-LDL uptake and degradation.

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This work was supported by USPHS Grants HE 6894, HE 12332, and HE 12358.

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