Short sequence-paper
A phylogenetic analysis of the cytochrome b and cytochrome c oxidase I genes supports an origin of mitochondria from within the Rickettsiaceae1

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Abstract

We have cloned and sequenced the genes encoding cytochrome b (cob) and cytochrome c oxidase subunit I (cox1) from Rickettsia prowazekii, a member of the α-proteobacteria. The phylogenetic analysis supports the hypothesis that mitochondria are derived from the α-proteobacteria and more specifically from within the Rickettsiaceae. We have estimated that the common ancestor of mitochondria and Rickettsiaceae dates back to more than 1500 million years ago.

Keywords

Mitochondrion
Cytochrome c oxidase 1
Cytochrome b
(Rickettsia prowazekii)

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1

The nucleotide sequences in this paper have been deposited in the EMBL sequence database under accession Nos. Y13854 (cob) and Y13855 (cox1).