Editorial
Epigenetics—New frontiers in neuroendocrinology

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  • Epigenetic memory of environmental organisms: A reflection of lifetime stressor exposures

    2014, Mutation Research - Genetic Toxicology and Environmental Mutagenesis
    Citation Excerpt :

    DNA methylation changes induced by this agent during embryogenesis have been identified as the cause of a range of disorders such as increased breast and testicular cancer in adult female and male offspring [59]. Exposure to oestrogens and a range of endocrine disruptors in early development has been shown to predispose to cancer in rodents and humans [60–62], alter hormonal responses later in life in the frog (Xenopus laevis) [63] and cause a range of reproductive and behavioural effects in rodents (reviewed in [34–36]). Specifically, methylation changes caused by diethylstilbestrol to c-fos and lactoferrin genes at the neonatal stage in mice contribute to an increased incidence of uterine cancer [64].

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