Structure
Volume 21, Issue 5, 7 May 2013, Pages 777-788
ArticleThe Glove-like Structure of the Conserved Membrane Protein TatC Provides Insight into Signal Sequence Recognition in Twin-Arginine Translocation
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Graphical Abstract
Highlights
► Crystal structures of TatC from the thermophile Aquifex aeolicus are presented ► The architecture of TatC generates a glove-shaped pocket buried in the bilayer ► Molecular dynamics reveal destabilization of the membrane around the pocket ► Correlation to biochemical results suggest the signal sequence binds in this pocket
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Present address: Division of Biochemical Sciences, National Chemical Laboratory, Pune 41108, India
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