Cell Stem Cell
Volume 7, Issue 1, 2 July 2010, Pages 101-113
ArticleAn RNAi Screen Identifies Msi2 and Prox1 as Having Opposite Roles in the Regulation of Hematopoietic Stem Cell Activity
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Graphical Abstract
Highlights
► RNAi screening examines roles of conserved polarity factors in HSC regulation ► Screen identified three HSC agonists (Msi2, Pard6a, Prkcz) and one antagonist (Prox1) ► Overexpression and knockdown of Msi2 and Prox1 gave reciprocal phenotypes ► Msi2 and Prox1 modulate the expression of self-renewal and cell cycle regulators
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Present address: Immune Signalling Laboratory, Cancer Immunology Research Division, and Department of Clinical Hematology, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria 3001, Australia
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