Elsevier

Neuroscience Letters

Volume 417, Issue 2, 1 May 2007, Pages 171-175
Neuroscience Letters

The neural basis of selection-for-action

https://doi.org/10.1016/j.neulet.2007.02.033Get rights and content

Abstract

The selection of objects in the visual environment is important in everyday life when acting in a goal-directed manner. Here we used functional magnetic resonance imaging (fMRI) to investigate brain activity while healthy subjects (N = 15) selectively reached to grasp a three-dimensional (3D) target stimulus presented either in isolation or in the presence of 3D non-target stimuli. A pneumatic MRI compatible apparatus was designed to precisely control the presentation of 3D graspable stimuli within the scanner. During scanning subjects were instructed to reach and grasp towards a target presented at an unknown location either in isolation or flanked by two distractor objects. Results indicated that reaching towards and grasping the target object in the presence of other non-target stimuli was associated with greater activation within the contralateral primary motor cortex and the precuneus as compared to the execution of reach-to-grasp movements towards the target presented in isolation. We conclude that the presence of non-targets evokes a differential level of neural activity within areas responsible for the planning and execution of selective reach-to-grasp movement.

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Acknowledgements

This research was supported by an Australian Research Council grant to UC and GE. We thank the Department of Radiography, Royal Children's Hospital, Melbourne and Max Rademacher for their technical expertise and support.

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