Climbing the Greatwall to Mitosis

doi:10.1016/j.molcel.2006.04.005

Molecular Cell

Volume 22, Issue 2, 21 April 2006, Pages 156-157

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Greatwall kinase is a conserved regulator of mitotic entry, and new work in Xenopus egg extracts (Yu et al., 2006) shows that Greatwall is required for the positive feedback loop that removes inhibitory tyrosine phosphate from the central mitotic regulatory kinase Cdc2.

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²: Present address: Genentech, Inc., South San Francisco, California 94080.

Molecular Cell

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Climbing the Greatwall to Mitosis