Original ArticleLate Preterm Birth and Risk of Developing Asthma
Section snippets
Methods
We conducted a retrospective cohort study using data from the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994) linked to US birth certificate data. This linked data set was compiled by the National Center for Health Statistics (NCHS)/Centers for Disease Control and Prevention. NHANES III is a nationally representative cross-sectional survey designed to assess the health and nutritional status of US adults and children. It uses a multistage probability sampling
Results
Table I shows the distribution of sociodemographic characteristics of the study population by duration of gestation (late preterm vs term). Of the 6187 children in the study, 537 (7.6%) were born late preterm and 370 (6.3%) had physician-diagnosed asthma (data not shown). Compared with infants born at term, those born late preterm were more likely to be non-Hispanic black and to have a mother age <20 years, a mother who smoked during pregnancy, and a family reference person with less than a
Discussion
Compared with infants born at term, infants born late preterm are more susceptible to respiratory morbidities during their birth hospitalization and neonatal period.4, 12, 13, 14 Our data indicate that late preterm birth was weakly associated with asthma risk in early childhood, but this association was not statistically significant. Other covariates, including male sex, black race, a parental history of asthma/hay fever, less education (head of household), young maternal age, and maternal
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Early childhood health and morbidity, including respiratory function in late preterm and early term births
2019, Seminars in Fetal and Neonatal MedicineCitation Excerpt :Children born preterm have been noted to secrete more cytokines, chemokines, growth factors and immunomodulatory mediators in nasopharyngeal aspirates done at 1 year when compared with children born at term, suggesting that they were more responsive to pro-inflammatory stimuli, as seen in asthma [57]. Although a study published in 2010 by Abe showed no association between LP birth and asthma [58], several studies have since indicated otherwise, finding increased risk of wheezing illness and asthma in the LP population. Boyle et al. demonstrated increased parent-reported wheezing and use of asthma medication at three and five years of age in LP and ET children participating in the UK Millennium Cohort Study, although the highest risk was seen in very preterm infants (Fig. 1).
Long-Term Pulmonary Outcome of Preterm Infants
2018, The Newborn Lung: Neonatology Questions and Controversies, Third EditionRisk of Asthma in Late Preterm Infants: A Propensity Score Approach
2015, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :We believe that the finding of no association between LPT and risk of asthma in our study is not due to lack of statistical power. For example, the literature showed that the effect size for the association between LPT and risk of asthma was 0.94-4.7.6,10,12-14,33 Given the sample size (n = 300 for each group), we had 80% power to detect an HR of 2.06.
Genetic, familial and environmental correlates of asthma among early adolescents in Sri Lanka: A case control study
2015, World Allergy Organization JournalCitation Excerpt :The univariate analysis revealed that born as the first child, only child, bed room overcrowding, exposure to cockroaches, presence of allergic rhinitis and other allergies, family history of asthma, allergic rhinitis and eczema were significantly associated with current asthma status of these early adolescents (Table 3). However, there was no significant association of male sex [24], low birth weight [25], pre term birth [26], exclusive breast feeding for 4 months [14], presence of overweight [27] exposure to traffic smoke or bed room overcrowding [14,28,29] or exposure to mould in the bed room with current asthma in the present univariate analysis. Past or present exposure to pets [30], family history of other allergies; present or past exposure to tobacco smoke [31] also failed to show significant relationships with current asthma status as per the univariate analysis.
Respiratory consequences of late preterm birth
2015, Paediatric Respiratory ReviewsCitation Excerpt :Not all studies have been in agreement, however, particularly at older ages. Data from 537 late preterm and 5650 term-born children in the Third National Health and Nutrition Examination Survey, for example, failed to demonstrate a significant increase in doctor-diagnosed asthma in children aged 2-83 months [45]. There are few studies and no prospective data describing long-term outcomes.
The immune consequences of preterm birth
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The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. The authors declare no conflicts of interest.