Clinical ResearchGlycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves
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This work was supported by National Institutes of Health grants R01s HL122805 (to Dr. Ferrari) and HL143008 (to Drs. Levy and Ferrari), T32s HL007915 (to Drs. Levy and Rock), HL007854 (to Dr. Kossar) and HL007343 (to Dr. Frasca), The Kibel Fund for Aortic Valve Research (to Drs. Ferrari and Levy), The Valley Hospital Foundation ’Marjorie C Bunnel’ charitable fund (to Drs. Ferrari and Grau), the American Diabetes Association Pathway to Stop Diabetes Grant 1-17-VSN-04 and the SENS Research Foundation (to Dr. Spiegel), and both Erin’s Fund and the William J Rashkind Endowment of the Children’s Hospital of Philadelphia (to Dr. Levy). Dr. Spiegel is cofounder and chief scientific adviser at REVEL Pharmaceuticals. Dr. Levy is a consultant for WL Gore. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC: Basic to Translational Science author instructions page.