Reply to the Letter to the EditorRe: Is actin the praziquantel receptor?
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Cited by (4)
Novel Therapeutic and Prevention Approaches for Schistosomiasis: Review
2013, Journal of Advanced ResearchCitation Excerpt :Therefore, reports of low drug efficacy [48–50] and schistosome resistance to the drug [39,51–55] have raised intense alarm. The likely possibility that PZQ binds and polymerizes schistosome and mammalian actin [56–60] should preclude its use in children, pregnant women, and individuals with vascular diseases [61]. Intense efforts are now directed at circumventing the flaw of having a single drug for such a dreadful infection via synthesizing derivatives of PZQ [39,62] and benzodiazepine schistosomicides [63], and examining their schistosomicidal activity in vitro and in vivo.
Praziquantel: Too Good to be Replaced?
2012, Parasitic Helminths: Targets, Screens, Drugs and VaccinesChemistry and pharmacology of neglected helminthic diseases
2011, Current Medicinal Chemistry
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