[Résonance Magnétique Nucléaire ex-situ]
. La Résonance Magnétique Nucléaire a révolutionné la science moderne par sa précision, par sa sélectivité et par son caractère non invasif. L'Imagerie par Résonance Magnétique et la Spectroscopie ont permis en effet l'obtention d'un grand nombre d'information pour des domaines aussi variés que les biomolécules, les matériaux, les organismes vivants ou les particules nanométriques. Une limitation majeure existe pourtant : toutes ces études ont lieu au laboratoire, car elles requièrent des aimants supraconducteurs très intenses et extrèmement homogènes. De plus, la taille maximale de l'object ou du sujet à étudier est limitée par les dimensions de l'aimant qui le contiendra. Les efforts pour contourner ces limitations ont conduit aux développements de systèmes de Résonance Magnétique portables. Leur utilisation est restée cependant principalement qualitative car l'information spectroscopique ne pouvait pas être obtenue. Nous avons introduit récemment une approche qui permet d'accéder à cette information spectrale même en présence de champ magnétique inhomogène. Elle est basée sur la corrélation entre le champ de radiofréquence effectif et le champs magnétique statique. Nous rapportons ici plusieurs implémentations pratiques de cette approche en discutant leurs perspectives en termes d'applicabilité et d'efficacité pour la RMN ex-situ.
Nuclear Magnetic Resonance has revolutionized modern science by its precision, selectivity and non-envasiveness. From complicated biomolecules to materials, from living organisms to nanometric particles, Magnetic Resonance Imaging and Spectroscopy have provided a wealth of invaluable information. Those studies take place in the laboratory, since they require strong and extremely homogeneous superconducting magnets and this represents a major limitation for the technique. Furthermore, the size of the object or subject to study is limited since it has to fit inside the bore of the magnet. Efforts to alleviate those problems lead to the recent development of portable magnetic resonance systems. Their use remained, however, mainly qualitative, since spectroscopic information could not be recovered. We have introduced recently an approach to regain this lost spectral information even in the presence of inhomogeneous magnetic fields. Our approach is based on the matching between the effect of the radio-frequency field and the effect of the static magnetic field. Several practical implementations will be reviewed and put in perspective for their applicability and efficiency in ex-situ NMR.
Mot clés : RMN ex-situ, Champs inhomogènes, Rotations Z, Champs corrélés, Impulsions adiabatiques, Impulsions composites, Détecteurs de RMN, Aimants ouverts, Système RMN à un coté
@article{CRPHYS_2004__5_3_337_0,
author = {Dimitris Sakellariou and Carlos A. Meriles and Alexander Pines},
title = {Advances in ex-situ {Nuclear} {Magnetic} {Resonance}},
journal = {Comptes Rendus. Physique},
pages = {337--347},
publisher = {Elsevier},
volume = {5},
number = {3},
year = {2004},
doi = {10.1016/j.crhy.2004.03.016},
language = {en},
}
Dimitris Sakellariou; Carlos A. Meriles; Alexander Pines. Advances in ex-situ Nuclear Magnetic Resonance. Comptes Rendus. Physique, Volume 5 (2004) no. 3, pp. 337-347. doi : 10.1016/j.crhy.2004.03.016. https://comptes-rendus.academie-sciences.fr/physique/articles/10.1016/j.crhy.2004.03.016/
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