Chemistry & Biology
Volume 22, Issue 3, 19 March 2015, Pages 317-328
Journal home page for Chemistry & Biology

Review
Biosynthetic Manipulation of Tryptophan in Bacteria: Pathways and Mechanisms

https://doi.org/10.1016/j.chembiol.2015.02.005Get rights and content
Under an Elsevier user license
open archive

Tryptophan, the most chemically complex and the least abundant of the 20 common proteinogenic amino acids, is a biosynthetic precursor to a large number of complex microbial natural products. Many of these molecules are promising scaffolds for drug discovery and development. The chemical features of tryptophan, including its ability to undergo enzymatic modifications at almost every atom in its structure and its propensity to undergo spontaneous, non-enzyme catalyzed chemistry, make it a unique biological precursor for the generation of chemical complexity. Here, we review the pathways that enable incorporation of tryptophan into complex metabolites in bacteria, with a focus on recently discovered, unusual metabolic transformations.

Cited by (0)