Chemistry & Biology
Volume 11, Issue 1, January 2004, Pages 14-16
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New Probes for Microtubule Dynamics

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Abstract

A phenotype-based screen identifies a purine analog, named diminutol, that perturbs the microtubule cytoskeleton in cells. An affinity-based approach identifies a protein target of this small molecule and leads to the characterization of a new pathway that may regulate cytoskeleton dynamics.

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