Cell
Volume 145, Issue 5, 27 May 2011, Pages 692-706
ArticleRecognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions
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Graphical Abstract
Highlights
► The BPTF protein recognizes two different histone posttranslational modifications ► Binding both these marks on one nucleosome increases affinity and specificity ► BPTF colocalizes with bivalently marked nucleosomes in the nucleus ► The binding pattern suggests mononucleosomal bivalent marks confer specificity in vivo
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Present address: Department of Molecular Genetics and Cell Biology, The University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
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Present address: School of Medicine, Tsinghua University, Beijing 100084, People's Republic of China
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Present address: MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, UK
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