Cancer Cell
Volume 22, Issue 3, 11 September 2012, Pages 359-372
ArticleIntegrative Analysis Reveals an Outcome-Associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B Cell Lymphoma
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Graphical Abstract
Highlights
► A complementary set of CNAs decrease p53 activity and deregulate cell cycle ► DLBCLs either have multiple CNAs of p53/cell cycle components or lack these lesions ► The p53/cell cycle CNAs predict outcome and suggest targeted treatment approaches ► DLBCLs with p53/cell cycle CNAs have increased genomic instability
Cited by (0)
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These authors contributed equally to this work
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Present address: Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA 02118, USA
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Present address: Sanofi-Aventis K. K., 163-1488 Tokyo, Japan
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Present address: Novartis, Cambridge, MA 02139, USA
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Present address: Infinity Pharmaceuticals, Cambridge, MA 02139, USA
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