Elsevier

Chinese Chemical Letters

Volume 22, Issue 12, December 2011, Pages 1439-1442
Chinese Chemical Letters

Facile synthesis of N-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases

https://doi.org/10.1016/j.cclet.2011.09.007Get rights and content

Abstract

Chemically modified cellular co-factors that provide function, such as immobilization or incorporation of fluorescent dyes, are valuable probes of biological activity. A convenient route to obtain S-adenosyl methionine (AdoMet) analogues modified at N-6 adenosine to feature a linker terminating in azide functionality is described herein. Subsequent decoration of such AdoMet analogues with guanidinium terminated linkers leads to novel potential bisubstrate inhibitors for protein arginine methyltransferases, PRMTs.

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Acknowledgments

This work was financially supported by the Medical Research Council Grant (No. G0700840) and the University of Nottingham (Studentship to Wei Hong).

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