Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II
Graphical abstract
A series of 4-amino-6-benzimidazole-pyrimidines were designed and synthesized as potent Lck inhibitors.
References and notes (11)
- et al.
Cell
(1992) - et al.
Bioorg. Med. Chem. Lett.
(2006) - et al.
Bioorg. Med. Chem. Lett.
(2003) - et al.
Bioorg. Med. Chem. Lett.
(2008) - et al.
Chem. Biol.
(2006)
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