A divergent chemoenzymatic route to an intermediate for nucleoside analogues
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Section snippets
Selected NMR (CDCl3, 200 MHz) data:
For 6a:δ 7.35–7.27 (5H, m, Ar-H), 4.35–4.33 (2H, m, H-5, ArCH2), 4.22–4.12 (4H, m, 2 × CH2OAc), 3.90 (1H, br m, ArCH2), 3.08 (3H, m, H-3, H-4), 2.08 (3H, s, OAc), 2.05 (3H, s, OAc).
For 1a: δ 7.43–7.25 (5H, m, Ar-H), 4.28 (2H, m, H-5, ArCH2), 4.02 (2H, m, CH2OAc), 3.80 (3H, m, CH2OH, ArCH2), 3.07 (2H, m, H-3), 2.35 (1H, m, H-4), 2.05 (3H, s, OAc).
For 2a:δ 7.35–7.29 (5H, m, Ar-H), 4.71 (1H, m, H-5), 4.41 (2H, m, ArCH2), 4.19 (2H, m, CH2OAc), 3.0 (4H, m, CH2OH, H-3), 2.40 (1H, m, H-4), 2.08 (3H, s,
Acknowledgements
Author A.B. expresses thanks to Council of Scientific and Industrial Research, Government of India, for funding.
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